Assay Detail
Functional
CHEMBL965144
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Antiangiogenic activity against BAEC assessed as inhibition of bFGF-induced cell proliferation in presence of 10% fetal bovine serum after 3 days by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Cell Type | BAEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bryoanthrathiophene, a new antiangiogenic constituent from the bryozoan Watersipora subtorquata (d'Orbigny, 1852).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.32 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL451954 | BRYOANTHRATHIOPHENE | — | 1 | 6.66 |
| CHEMBL53418 | DANTHRON | 4.0 | 1 | 4.70 |
| CHEMBL484048 | — | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL451954 | BRYOANTHRATHIOPHENE | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL53418 | DANTHRON | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL484048 | — | IC50 | = | 25800.0 | nM | 4.59 |