Assay Detail
Binding
CHEMBL965244
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Binding affinity to 5HT1A receptor
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.52 | 9.02 |
| IC50 | 1 | 8.74 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31217 | — | — | 1 | 9.02 |
| CHEMBL144030 | — | — | 1 | 8.80 |
| CHEMBL22744 | — | — | 1 | 8.74 |
| CHEMBL158941 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31217 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL144030 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL22744 | — | IC50 | = | 1.83 | nM | 8.74 |
| CHEMBL158941 | — | Ki | = | 17.7 | nM | 7.75 |