Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL965323

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of DPP8
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Dipeptidyl peptidase 8 (CHEMBL4657)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design.
Liang GB, Qian X, Biftu T, Singh S, Gao YD, Scapin G, Patel S, Leiting B, Patel R, Wu J, Zhang X, Thornberry NA, Weber AE.
Bioorg Med Chem Lett (2008) 18 : 3706 -3710
PubMed 18524582 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 4.54 5.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL433572 1 5.68
CHEMBL510073 1 4.82
CHEMBL512887 1 4.77
CHEMBL527424 1 4.75
CHEMBL488484 1 4.57
CHEMBL452297 1 4.57
CHEMBL452290 1 4.41
CHEMBL507738 1 4.39
CHEMBL488678 1 4.37
CHEMBL488637 1 4.33
CHEMBL471936 1 4.19
CHEMBL388475 1 4.12
CHEMBL452805 1 4.06
CHEMBL452289 1 -
CHEMBL512895 1 -
CHEMBL472123 1 -
CHEMBL442673 1 -
CHEMBL472124 1 -
CHEMBL504506 1 -
CHEMBL527198 1 -
CHEMBL488469 1 -
CHEMBL519591 1 -
CHEMBL487630 1 -
CHEMBL520067 1 -
CHEMBL220249 1 -
CHEMBL507719 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL433572 IC50 = 2100.0 nM 5.68
CHEMBL510073 IC50 = 15000.0 nM 4.82
CHEMBL512887 IC50 = 17000.0 nM 4.77
CHEMBL527424 IC50 = 18000.0 nM 4.75
CHEMBL488484 IC50 = 27000.0 nM 4.57
CHEMBL452297 IC50 = 27000.0 nM 4.57
CHEMBL452290 IC50 = 39000.0 nM 4.41
CHEMBL507738 IC50 = 41000.0 nM 4.39
CHEMBL488678 IC50 = 43000.0 nM 4.37
CHEMBL488637 IC50 = 47000.0 nM 4.33
CHEMBL471936 IC50 = 64000.0 nM 4.19
CHEMBL388475 IC50 = 75000.0 nM 4.12
CHEMBL452805 IC50 = 87000.0 nM 4.06
CHEMBL452289 IC50 > 100000.0 nM -
CHEMBL512895 IC50 > 100000.0 nM -
CHEMBL472123 IC50 > 100000.0 nM -
CHEMBL442673 IC50 > 100000.0 nM -
CHEMBL472124 IC50 > 100000.0 nM -
CHEMBL504506 IC50 > 100000.0 nM -
CHEMBL527198 IC50 > 100000.0 nM -
CHEMBL488469 IC50 > 100000.0 nM -
CHEMBL519591 IC50 > 100000.0 nM -
CHEMBL487630 IC50 > 100000.0 nM -
CHEMBL520067 IC50 > 100000.0 nM -
CHEMBL220249 IC50 > 100000.0 nM -
CHEMBL507719 IC50 > 100000.0 nM -