Compound Detail
CHEMBL388475
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL388475 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZLZZDLNHNLSAJF-LLVKDONJSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
371.3
MW (Da)
1.74
ALogP
5
HBA
1
HBD
77.0
PSA (Ų)
0.83
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.01
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 CHEMBL284 | IC50 | 7.01 | 7.01 | 98.0 | 2 |
| Dipeptidyl peptidase 8 CHEMBL4657 | IC50 | 4.12 | 4.12 | 75000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 | IC50 | = | 98.0 | nM | 7.01 | Inhibition of DPP4 activity | 17434732 |
| Dipeptidyl peptidase 4 | IC50 | = | 98.0 | nM | 7.01 | Inhibition of DPP4 | 18524582 |
| Dipeptidyl peptidase 8 | IC50 | = | 75000.0 | nM | 4.12 | Inhibition of DPP8 activity | 17434732 |
| Dipeptidyl peptidase 8 | IC50 | = | 75000.0 | nM | 4.12 | Inhibition of DPP8 | 18524582 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17434732 | 10.1016/j.bmcl.2007.03.098 | Dipeptidyl peptidase 4 | 1 |
| 17434732 | 10.1016/j.bmcl.2007.03.098 | Dipeptidyl peptidase 8 | 1 |
| 17434732 | 10.1016/j.bmcl.2007.03.098 | Dipeptidyl peptidase 9 | 1 |
| 18524582 | 10.1016/j.bmcl.2008.05.061 | Dipeptidyl peptidase 4 | 1 |
| 18524582 | 10.1016/j.bmcl.2008.05.061 | Dipeptidyl peptidase 8 | 1 |
Data from ChEMBL 36 via Core Engine