Assay Detail
Binding
CHEMBL965384
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Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
7-aryl 1,5-dihydro-benzo[e][1,4]oxazepin-2-ones and analogs as non-steroidal progesterone receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 7.27 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 9.70 |
| CHEMBL501080 | — | — | 1 | 7.93 |
| CHEMBL117518 | — | — | 1 | 7.89 |
| CHEMBL487116 | — | — | 1 | 7.88 |
| CHEMBL486709 | — | — | 1 | 7.83 |
| CHEMBL487727 | — | — | 1 | 7.82 |
| CHEMBL488758 | — | — | 1 | 7.80 |
| CHEMBL487117 | — | — | 1 | 7.65 |
| CHEMBL487728 | — | — | 1 | 7.60 |
| CHEMBL486498 | — | — | 1 | 7.58 |
| CHEMBL519581 | — | — | 1 | 7.54 |
| CHEMBL530108 | — | — | 1 | 7.53 |
| CHEMBL488558 | — | — | 1 | 7.52 |
| CHEMBL529665 | — | — | 1 | 7.52 |
| CHEMBL486915 | — | — | 1 | 7.52 |
| CHEMBL530109 | — | — | 1 | 7.47 |
| CHEMBL487729 | — | — | 1 | 7.46 |
| CHEMBL506297 | — | — | 1 | 7.23 |
| CHEMBL486499 | — | — | 1 | 7.21 |
| CHEMBL520223 | — | — | 1 | 7.20 |
| CHEMBL519883 | — | — | 1 | 7.19 |
| CHEMBL487930 | — | — | 1 | 7.18 |
| CHEMBL488560 | — | — | 1 | 7.11 |
| CHEMBL488559 | — | — | 1 | 7.08 |
| CHEMBL527871 | — | — | 1 | 7.06 |
| CHEMBL486910 | — | — | 1 | 7.00 |
| CHEMBL519394 | — | — | 1 | 7.00 |
| CHEMBL486433 | — | — | 1 | 6.98 |
| CHEMBL486916 | — | — | 1 | 6.97 |
| CHEMBL488556 | — | — | 1 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL501080 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL117518 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL487116 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL486709 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL487727 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL488758 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL487117 | — | IC50 | = | 22.5 | nM | 7.65 |
| CHEMBL487728 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL486498 | — | IC50 | = | 26.6 | nM | 7.58 |
| CHEMBL519581 | — | IC50 | = | 29.1 | nM | 7.54 |
| CHEMBL530108 | — | IC50 | = | 29.3 | nM | 7.53 |
| CHEMBL488558 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL529665 | — | IC50 | = | 30.1 | nM | 7.52 |
| CHEMBL486915 | — | IC50 | = | 29.9 | nM | 7.52 |
| CHEMBL530109 | — | IC50 | = | 34.1 | nM | 7.47 |
| CHEMBL487729 | — | IC50 | = | 34.6 | nM | 7.46 |
| CHEMBL506297 | — | IC50 | = | 59.2 | nM | 7.23 |
| CHEMBL486499 | — | IC50 | = | 62.1 | nM | 7.21 |
| CHEMBL520223 | — | IC50 | = | 62.5 | nM | 7.20 |
| CHEMBL519883 | — | IC50 | = | 65.2 | nM | 7.19 |
| CHEMBL487930 | — | IC50 | = | 65.5 | nM | 7.18 |
| CHEMBL488560 | — | IC50 | = | 78.2 | nM | 7.11 |
| CHEMBL488559 | — | IC50 | = | 82.4 | nM | 7.08 |
| CHEMBL527871 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL486910 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL519394 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL486433 | — | IC50 | = | 104.7 | nM | 6.98 |
| CHEMBL486916 | — | IC50 | = | 107.6 | nM | 6.97 |
| CHEMBL488556 | — | IC50 | = | 116.7 | nM | 6.93 |
| CHEMBL530107 | — | IC50 | = | 138.3 | nM | 6.86 |
| CHEMBL520534 | — | IC50 | = | 207.7 | nM | 6.68 |
| CHEMBL486707 | — | IC50 | = | 349.4 | nM | 6.46 |
| CHEMBL488351 | — | IC50 | = | 365.7 | nM | 6.44 |
| CHEMBL519560 | — | IC50 | = | 676.7 | nM | 6.17 |
| CHEMBL488557 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL521049 | — | IC50 | = | 1000.0 | nM | 6.00 |