Assay Detail

CHEMBL965596

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Binding

Inhibition of CDK9/Cyclin T

ChEMBL ↗

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Target

CDK9/cyclin T1 (CHEMBL2111389) ↗

Open DB target context

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CDK9/cyclin T1 (CHEMBL2111389) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target CDK9/cyclin T1

CHEMBL2111389

Anchored from Assay target.

Protein identity CDK9/cyclin T1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	6 — Multiple protein complex / RNA
Curated By	Autocuration

Target

CDK9/cyclin T1 (CHEMBL2111389) ↗

Type	PROTEIN COMPLEX
Organism	Homo sapiens

Publication

Modifications of the isonipecotic acid fragment of SNS-032: analogs with improved permeability and lower efflux ratio.

Fan J, Fahr B, Stockett D, Chan E, Cheeti S, Serafimova I, Lu Y, Pham P, Walker DH, Hoch U, Choong IC.
Bioorg Med Chem Lett (2008) 18 : 6236 -6239
PubMed 18926699 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.40	8.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL296468	BMS-387032	1.0	1	8.40
CHEMBL452602	—	—	1	8.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL296468	BMS-387032	IC50	=	4.0	nM	8.40
CHEMBL452602	—	IC50	=	4.0	nM	8.40