Assay Detail
Functional
CHEMBL965747
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Growth inhibition of paclitaxel-resistant human NCI/ADR cells after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI/ADR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Total synthesis and biological evaluation of novel C2-C6 region analogues of dictyostatin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.58 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226880 | DICTYOSTATIN | — | 1 | 8.18 |
| CHEMBL461149 | — | — | 1 | 7.37 |
| CHEMBL459221 | — | — | 1 | 7.18 |
| CHEMBL479733 | — | — | 1 | 6.89 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.89 |
| CHEMBL226932 | — | — | 1 | 5.82 |
| CHEMBL474680 | — | — | 1 | 5.80 |
| CHEMBL475687 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226880 | DICTYOSTATIN | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL461149 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL459221 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL479733 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL226932 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL474680 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL475687 | — | IC50 | = | 3100.0 | nM | 5.51 |