Assay Detail
Binding
CHEMBL965759
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Inhibition of histidine-tagged human recombinant Cdc25B catalytic domain expressed in Escherichia coli
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.72 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476648 | ADOCIAQUINONE B | — | 1 | 6.96 |
| CHEMBL50620 | — | — | 1 | 6.57 |
| CHEMBL478485 | — | — | 1 | 6.06 |
| CHEMBL500348 | — | — | 1 | 6.03 |
| CHEMBL274056 | NAPHTHAZALIN | — | 1 | 6.00 |
| CHEMBL43612 | JUGLONE | — | 1 | 5.70 |
| CHEMBL476655 | — | — | 1 | 5.64 |
| CHEMBL55934 | NAPHTHOQUINONE | — | 1 | 5.56 |
| CHEMBL590 | MENADIONE | 4.0 | 1 | 5.47 |
| CHEMBL55659 | ANTHRAQUINONE | — | 1 | 5.02 |
| CHEMBL508233 | — | — | 1 | 5.02 |
| CHEMBL476649 | — | — | 1 | 4.65 |
| CHEMBL8320 | BENZOQUINONE | — | 1 | - |
| CHEMBL462058 | — | — | 1 | - |
| CHEMBL505950 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476648 | ADOCIAQUINONE B | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL50620 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL478485 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL500348 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL274056 | NAPHTHAZALIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL43612 | JUGLONE | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL476655 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL55934 | NAPHTHOQUINONE | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL590 | MENADIONE | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL55659 | ANTHRAQUINONE | IC50 | = | 9510.0 | nM | 5.02 |
| CHEMBL508233 | — | IC50 | = | 9530.0 | nM | 5.02 |
| CHEMBL476649 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL8320 | BENZOQUINONE | IC50 | > | 50000.0 | nM | - |
| CHEMBL462058 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL505950 | — | IC50 | > | 50000.0 | nM | - |