Assay Detail
Binding
CHEMBL965857
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Inhibition of rat liver FAS by Coomassie blue staining
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel fatty acid synthase (FAS) inhibitors: design, synthesis, biological evaluation, and molecular docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.03 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477462 | — | — | 1 | 6.10 |
| CHEMBL478276 | — | — | 1 | 5.92 |
| CHEMBL478275 | — | — | 1 | 5.64 |
| CHEMBL475472 | — | — | 1 | 5.59 |
| CHEMBL449993 | — | — | 1 | 4.81 |
| CHEMBL476446 | — | — | 1 | 4.78 |
| CHEMBL478136 | — | — | 1 | 4.71 |
| CHEMBL518275 | — | — | 1 | 4.62 |
| CHEMBL517501 | — | — | 1 | 4.56 |
| CHEMBL478502 | — | — | 1 | 4.53 |
| CHEMBL478313 | — | — | 1 | 4.05 |
| CHEMBL476665 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477462 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL478276 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL478275 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL475472 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL449993 | — | IC50 | = | 15530.0 | nM | 4.81 |
| CHEMBL476446 | — | IC50 | = | 16730.0 | nM | 4.78 |
| CHEMBL478136 | — | IC50 | = | 19470.0 | nM | 4.71 |
| CHEMBL518275 | — | IC50 | = | 24150.0 | nM | 4.62 |
| CHEMBL517501 | — | IC50 | = | 27460.0 | nM | 4.56 |
| CHEMBL478502 | — | IC50 | = | 29780.0 | nM | 4.53 |
| CHEMBL478313 | — | IC50 | = | 88640.0 | nM | 4.05 |
| CHEMBL476665 | — | IC50 | = | 122400.0 | nM | - |