Assay Detail
Functional
CHEMBL965965
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Cytotoxicity against drug-resistant human KB-3-1 cells by MTS/PMS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB 3-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro cytotoxic activity of phenanthroindolizidine alkaloids from Cynanchum vincetoxicum and Tylophora tanakae against drug-sensitive and multidrug-resistant cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.93 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484042 | — | — | 1 | 8.15 |
| CHEMBL484050 | — | — | 1 | 7.82 |
| CHEMBL228286 | (-)-ANTOFINE | — | 1 | 7.80 |
| CHEMBL520783 | — | — | 1 | 7.37 |
| CHEMBL258137 | TYLOPHORINE | — | 1 | 6.67 |
| CHEMBL483227 | — | — | 1 | 6.39 |
| CHEMBL176049 | RHODAMINE123 | — | 1 | 5.66 |
| CHEMBL483226 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484042 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL484050 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL228286 | (-)-ANTOFINE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL520783 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL258137 | TYLOPHORINE | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL483227 | — | IC50 | = | 403.0 | nM | 6.39 |
| CHEMBL176049 | RHODAMINE123 | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL483226 | — | IC50 | = | 2630.0 | nM | 5.58 |