Assay Detail
Binding
CHEMBL966086
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Inhibition of mushroom tyrosinase
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.16 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL500557 | — | — | 1 | 7.07 |
| CHEMBL483262 | — | — | 1 | 6.77 |
| CHEMBL452107 | — | — | 1 | 6.70 |
| CHEMBL449882 | — | — | 1 | 6.64 |
| CHEMBL458405 | — | — | 1 | 6.55 |
| CHEMBL121188 | TROPOLONE | — | 1 | 6.40 |
| CHEMBL401926 | — | — | 1 | 6.38 |
| CHEMBL272958 | — | — | 1 | 6.27 |
| CHEMBL467890 | — | — | 1 | 6.21 |
| CHEMBL466982 | — | — | 1 | 6.07 |
| CHEMBL510328 | — | — | 1 | 6.02 |
| CHEMBL505588 | — | — | 1 | 6.00 |
| CHEMBL388025 | CINNAMALDEHYDE THIOSEMICARBAZONE | — | 1 | 5.57 |
| CHEMBL444251 | — | — | 1 | 4.94 |
| CHEMBL450696 | — | — | 1 | 4.82 |
| CHEMBL95770 | 4-METHOXYCINNAMIC ACID | — | 1 | - |
| CHEMBL232202 | ARBUTIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL500557 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL483262 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL452107 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL449882 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL458405 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL121188 | TROPOLONE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL401926 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL272958 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL467890 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL466982 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL510328 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL505588 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL388025 | CINNAMALDEHYDE THIOSEMICARBAZONE | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL444251 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL450696 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL95770 | 4-METHOXYCINNAMIC ACID | IC50 | = | 410000.0 | nM | - |
| CHEMBL232202 | ARBUTIN | IC50 | = | 10400000.0 | nM | - |