Assay Detail
Binding
CHEMBL966653
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Inhibition of human Tpl2 by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 8 (CHEMBL4899) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.72 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436817 | — | — | 1 | 7.92 |
| CHEMBL199230 | — | — | 1 | 7.80 |
| CHEMBL370336 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436817 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL199230 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL370336 | — | IC50 | = | 36000.0 | nM | 4.44 |