Assay Detail
Binding
CHEMBL967913
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Binding affinity to human adenosine A2A receptor
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 8.96 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245848 | — | — | 1 | 10.00 |
| CHEMBL22717 | — | — | 1 | 9.92 |
| CHEMBL373700 | — | — | 1 | 9.70 |
| CHEMBL16687 | CGS-15943 | — | 1 | 9.40 |
| CHEMBL469026 | — | — | 1 | 9.30 |
| CHEMBL17127 | SCH-58261 | — | 1 | 9.22 |
| CHEMBL360241 | — | — | 1 | 9.10 |
| CHEMBL113142 | ZM-241385 | — | 1 | 9.10 |
| CHEMBL373026 | — | — | 1 | 9.00 |
| CHEMBL261203 | — | — | 1 | 8.96 |
| CHEMBL359463 | — | — | 1 | 8.96 |
| CHEMBL281129 | — | — | 1 | 8.92 |
| CHEMBL407307 | — | — | 1 | 8.85 |
| CHEMBL513009 | — | — | 1 | 8.40 |
| CHEMBL177782 | — | — | 1 | 8.37 |
| CHEMBL274274 | — | — | 1 | 8.19 |
| CHEMBL197669 | ST1535 | 1.0 | 1 | 8.18 |
| CHEMBL165760 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245848 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL22717 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL373700 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL16687 | CGS-15943 | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL469026 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL17127 | SCH-58261 | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL360241 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL113142 | ZM-241385 | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL373026 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL261203 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL359463 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL281129 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL407307 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL513009 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL177782 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL274274 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL197669 | ST1535 | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL165760 | — | Ki | = | 20.0 | nM | 7.70 |