Assay Detail
Binding
CHEMBL967995
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Inhibition of human erythrocyte AChE by Ellman's method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.43 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374184 | — | — | 1 | 6.96 |
| CHEMBL218939 | — | — | 1 | 6.92 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.82 |
| CHEMBL219406 | — | — | 1 | 6.77 |
| CHEMBL219172 | — | — | 1 | 6.72 |
| CHEMBL468001 | — | — | 1 | 6.43 |
| CHEMBL513161 | — | — | 1 | 6.17 |
| CHEMBL512096 | — | — | 1 | 6.15 |
| CHEMBL468000 | — | — | 1 | 5.80 |
| CHEMBL468002 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374184 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL218939 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL95 | TACRINE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL219406 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL219172 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL468001 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL513161 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL512096 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL468000 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL468002 | — | IC50 | = | 2800.0 | nM | 5.55 |