Assay Detail
Functional
CHEMBL968025
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Antiproliferative activity against human SH-SY5Y cells assessed as survival after 48 hrs by MTS reduction assay
42
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.14 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518800 | — | — | 1 | 6.37 |
| CHEMBL461367 | — | — | 1 | 6.13 |
| CHEMBL460946 | — | — | 1 | 6.12 |
| CHEMBL461557 | — | — | 1 | 6.12 |
| CHEMBL460947 | — | — | 1 | 6.03 |
| CHEMBL518190 | — | — | 1 | 5.90 |
| CHEMBL461556 | — | — | 1 | 5.77 |
| CHEMBL510179 | — | — | 1 | 5.62 |
| CHEMBL455129 | — | — | 1 | 5.48 |
| CHEMBL460945 | — | — | 1 | 5.19 |
| CHEMBL472513 | — | — | 1 | 5.19 |
| CHEMBL470974 | — | — | 1 | 5.18 |
| CHEMBL470969 | — | — | 1 | 5.16 |
| CHEMBL451792 | — | — | 1 | 5.13 |
| CHEMBL459676 | — | — | 1 | 5.12 |
| CHEMBL455389 | — | — | 1 | 5.11 |
| CHEMBL472514 | — | — | 1 | 5.05 |
| CHEMBL518813 | — | — | 1 | 5.00 |
| CHEMBL451806 | — | — | 1 | 4.96 |
| CHEMBL520235 | — | — | 2 | 4.94 |
| CHEMBL518014 | — | — | 1 | 4.81 |
| CHEMBL461948 | — | — | 1 | 4.80 |
| CHEMBL461764 | — | — | 1 | 4.80 |
| CHEMBL514117 | — | — | 1 | 4.78 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 4.76 |
| CHEMBL511845 | — | — | 1 | 4.76 |
| CHEMBL215919 | — | — | 1 | 4.76 |
| CHEMBL486632 | — | — | 1 | 4.57 |
| CHEMBL487637 | — | — | 1 | 4.54 |
| CHEMBL452065 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518800 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL461367 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL461557 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL460946 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL460947 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL518190 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL461556 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL510179 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL455129 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL460945 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL472513 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL470974 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL470969 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL451792 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL459676 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL455389 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL472514 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL518813 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL451806 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL520235 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL518014 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL461948 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL461764 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL514117 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL215919 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL511845 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL486632 | — | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL487637 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL452065 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL520235 | — | IC50 | = | 37600.0 | nM | 4.42 |
| CHEMBL503530 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL455641 | — | IC50 | = | 64800.0 | nM | 4.19 |
| CHEMBL133342 | (S)-ROSCOVITINE | IC50 | - | — | - | |
| CHEMBL454617 | — | IC50 | = | 165100.0 | nM | - |
| CHEMBL455388 | — | IC50 | - | — | - | |
| CHEMBL509237 | — | IC50 | - | — | - | |
| CHEMBL454877 | — | IC50 | - | — | - | |
| CHEMBL487468 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL518655 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL487469 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL519576 | — | IC50 | > | 100000.0 | nM | - |