Assay Detail
ADMET
CHEMBL968026
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Antiproliferative activity against HEK293 cells assessed as survival after 48 hrs by MTS reduction assay
42
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.21 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518800 | — | — | 1 | 6.25 |
| CHEMBL461367 | — | — | 1 | 6.12 |
| CHEMBL460946 | — | — | 1 | 6.05 |
| CHEMBL461557 | — | — | 1 | 5.88 |
| CHEMBL461556 | — | — | 1 | 5.81 |
| CHEMBL518190 | — | — | 1 | 5.66 |
| CHEMBL510179 | — | — | 1 | 5.60 |
| CHEMBL455129 | — | — | 1 | 5.55 |
| CHEMBL451792 | — | — | 1 | 5.28 |
| CHEMBL470974 | — | — | 1 | 5.20 |
| CHEMBL487637 | — | — | 1 | 5.18 |
| CHEMBL472513 | — | — | 1 | 5.13 |
| CHEMBL470969 | — | — | 1 | 5.10 |
| CHEMBL472514 | — | — | 1 | 5.08 |
| CHEMBL459676 | — | — | 1 | 5.04 |
| CHEMBL518813 | — | — | 1 | 4.98 |
| CHEMBL461764 | — | — | 1 | 4.94 |
| CHEMBL511845 | — | — | 1 | 4.84 |
| CHEMBL451806 | — | — | 1 | 4.81 |
| CHEMBL520235 | — | — | 2 | 4.78 |
| CHEMBL460945 | — | — | 1 | 4.70 |
| CHEMBL455389 | — | — | 1 | 4.69 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 4.33 |
| CHEMBL455641 | — | — | 1 | 4.13 |
| CHEMBL133342 | (S)-ROSCOVITINE | — | 1 | - |
| CHEMBL454877 | — | — | 1 | - |
| CHEMBL452065 | — | — | 1 | - |
| CHEMBL487469 | — | — | 1 | - |
| CHEMBL519576 | — | — | 1 | - |
| CHEMBL486632 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518800 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL461367 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL460946 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL461557 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL461556 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL518190 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL510179 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL455129 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL451792 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL470974 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL487637 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL472513 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL470969 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL472514 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL459676 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL518813 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL461764 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL511845 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL451806 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL520235 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL460945 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL455389 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 46700.0 | nM | 4.33 |
| CHEMBL455641 | — | IC50 | = | 73700.0 | nM | 4.13 |
| CHEMBL460947 | — | IC50 | - | — | - | |
| CHEMBL503530 | — | IC50 | - | — | - | |
| CHEMBL215919 | — | IC50 | - | — | - | |
| CHEMBL454877 | — | IC50 | - | — | - | |
| CHEMBL509237 | — | IC50 | - | — | - | |
| CHEMBL455388 | — | IC50 | - | — | - | |
| CHEMBL454617 | — | IC50 | = | 190000.0 | nM | - |
| CHEMBL487468 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL514117 | — | IC50 | - | — | - | |
| CHEMBL452065 | — | IC50 | - | — | - | |
| CHEMBL461948 | — | IC50 | - | — | - | |
| CHEMBL520235 | — | IC50 | - | — | - | |
| CHEMBL518014 | — | IC50 | - | — | - | |
| CHEMBL487469 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL519576 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL486632 | — | IC50 | - | — | - | |
| CHEMBL518655 | — | IC50 | - | — | - | |
| CHEMBL133342 | (S)-ROSCOVITINE | IC50 | - | — | - |