Assay Detail
Functional
CHEMBL968125
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Cytotoxicity against human KB cells after 72 hrs
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.17 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 8.10 |
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 1 | 5.13 |
| CHEMBL492162 | USHINSUNINE | — | 1 | 4.37 |
| CHEMBL443099 | OCOTEINE | — | 1 | 4.13 |
| CHEMBL491511 | COLUMBAMINE CHLORIDE | — | 1 | 4.11 |
| CHEMBL493439 | EMETINE HYDROCHLORIDE | 2.0 | 1 | - |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | - |
| CHEMBL490533 | CANADINE | — | 1 | - |
| CHEMBL486179 | PROTOPINE | — | 1 | - |
| CHEMBL520043 | ALLOCRYPTOPINE | — | 1 | - |
| CHEMBL491544 | THALIFENDINE | — | 1 | - |
| CHEMBL274346 | JATRORRHIZINE CHLORIDE | — | 1 | - |
| CHEMBL490509 | DEHYDRODISCRETINE CHLORIDE | — | 1 | - |
| CHEMBL248095 | SINOMENINE | 3.0 | 1 | - |
| CHEMBL404097 | SALUTARIDINE | — | 1 | - |
| CHEMBL490139 | O-METHYLFLAVINANTINE | — | 1 | - |
| CHEMBL492163 | METAPHANINE HYDROBROMIDE | — | 1 | - |
| CHEMBL494053 | NORCORYDINE | — | 1 | - |
| CHEMBL494052 | MAGNOFLORINE IODIDE | — | 1 | - |
| CHEMBL489525 | ISOCORYDINE | — | 1 | - |
| CHEMBL522429 | DEHYDROOCOTEINE | — | 1 | - |
| CHEMBL489524 | CORYDINE | — | 1 | - |
| CHEMBL486380 | CATALPIFOLINE | — | 1 | - |
| CHEMBL450614 | THALICMININE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL12089 | BERBERINE CHLORIDE | IC50 | = | 7320.0 | nM | 5.13 |
| CHEMBL492162 | USHINSUNINE | IC50 | = | 42500.0 | nM | 4.37 |
| CHEMBL443099 | OCOTEINE | IC50 | = | 74300.0 | nM | 4.13 |
| CHEMBL491511 | COLUMBAMINE CHLORIDE | IC50 | = | 77900.0 | nM | 4.11 |
| CHEMBL493439 | EMETINE HYDROCHLORIDE | IC50 | - | — | - | |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | - | — | - | |
| CHEMBL490533 | CANADINE | IC50 | > | 734000.0 | nM | - |
| CHEMBL486179 | PROTOPINE | IC50 | > | 354000.0 | nM | - |
| CHEMBL520043 | ALLOCRYPTOPINE | IC50 | > | 338000.0 | nM | - |
| CHEMBL491544 | THALIFENDINE | IC50 | > | 699000.0 | nM | - |
| CHEMBL274346 | JATRORRHIZINE CHLORIDE | IC50 | > | 335000.0 | nM | - |
| CHEMBL490509 | DEHYDRODISCRETINE CHLORIDE | IC50 | > | 335000.0 | nM | - |
| CHEMBL248095 | SINOMENINE | IC50 | > | 759000.0 | nM | - |
| CHEMBL404097 | SALUTARIDINE | IC50 | > | 764000.0 | nM | - |
| CHEMBL490139 | O-METHYLFLAVINANTINE | IC50 | > | 734000.0 | nM | - |
| CHEMBL492163 | METAPHANINE HYDROBROMIDE | IC50 | > | 586000.0 | nM | - |
| CHEMBL494053 | NORCORYDINE | IC50 | > | 733000.0 | nM | - |
| CHEMBL494052 | MAGNOFLORINE IODIDE | IC50 | > | 533000.0 | nM | - |
| CHEMBL489525 | ISOCORYDINE | IC50 | > | 733000.0 | nM | - |
| CHEMBL522429 | DEHYDROOCOTEINE | IC50 | > | 341000.0 | nM | - |
| CHEMBL489524 | CORYDINE | IC50 | > | 733000.0 | nM | - |
| CHEMBL486380 | CATALPIFOLINE | IC50 | > | 733000.0 | nM | - |
| CHEMBL450614 | THALICMININE | IC50 | > | 685000.0 | nM | - |