Assay Detail
Binding
CHEMBL968427
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Inhibition of aldose reductase in rat lenses
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design and synthesis of N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides as aldose reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.81 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 6.60 |
| CHEMBL507525 | — | — | 1 | 4.85 |
| CHEMBL458588 | — | — | 1 | 4.81 |
| CHEMBL285053 | — | — | 1 | 4.80 |
| CHEMBL444802 | — | — | 1 | 4.51 |
| CHEMBL458568 | — | — | 1 | 4.48 |
| CHEMBL457486 | — | — | 1 | 4.35 |
| CHEMBL288404 | — | — | 1 | 4.10 |
| CHEMBL37054 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266497 | SORBINIL | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL507525 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL458588 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL285053 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL444802 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL458568 | — | IC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL457486 | — | IC50 | = | 44400.0 | nM | 4.35 |
| CHEMBL288404 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL37054 | — | IC50 | = | 134000.0 | nM | - |