Assay Detail
Functional
CHEMBL968439
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse PPARgamma by chimeric transactivation assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL2459) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.66 | 6.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477095 | — | — | 1 | 6.99 |
| CHEMBL479002 | — | — | 1 | 6.82 |
| CHEMBL478725 | — | — | 1 | 6.57 |
| CHEMBL477323 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477095 | — | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL479002 | — | EC50 | = | 151.0 | nM | 6.82 |
| CHEMBL478725 | — | EC50 | = | 272.0 | nM | 6.57 |
| CHEMBL477323 | — | EC50 | = | 536.0 | nM | 6.27 |