Assay Detail
Binding
CHEMBL968446
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Wistar rat lens aldose reductase 2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Carboxymethylated pyridoindole antioxidants as aldose reductase inhibitors: Synthesis, activity, partitioning, and molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.52 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | 2.0 | 1 | 8.30 |
| CHEMBL476908 | — | — | 1 | 4.78 |
| CHEMBL477942 | — | — | 1 | 4.74 |
| CHEMBL477933 | — | — | 1 | 4.27 |
| CHEMBL303192 | DEHYDROSTOBADINE | — | 1 | - |
| CHEMBL479176 | STOBADINE | — | 1 | - |
| CHEMBL479175 | — | — | 1 | - |
| CHEMBL479174 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL476908 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL477942 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL477933 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL303192 | DEHYDROSTOBADINE | IC50 | > | 1000000.0 | nM | - |
| CHEMBL479176 | STOBADINE | IC50 | > | 1000000.0 | nM | - |
| CHEMBL479175 | — | IC50 | = | 266000.0 | nM | - |
| CHEMBL479174 | — | IC50 | = | 380700.0 | nM | - |