Assay Detail
Functional
CHEMBL968449
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Antioxidant activity assessed as inhibition of AAPH-induced peroxidation of DOPC liposome after 80 mins by thiocyanate method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Carboxymethylated pyridoindole antioxidants as aldose reductase inhibitors: Synthesis, activity, partitioning, and molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.22 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL479176 | STOBADINE | — | 1 | 4.60 |
| CHEMBL303192 | DEHYDROSTOBADINE | — | 1 | 4.14 |
| CHEMBL479175 | — | — | 1 | 4.12 |
| CHEMBL153 | TROLOX | — | 1 | 4.03 |
| CHEMBL477933 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL479176 | STOBADINE | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL303192 | DEHYDROSTOBADINE | IC50 | = | 72700.0 | nM | 4.14 |
| CHEMBL479175 | — | IC50 | = | 75600.0 | nM | 4.12 |
| CHEMBL153 | TROLOX | IC50 | = | 93500.0 | nM | 4.03 |
| CHEMBL477933 | — | IC50 | = | 168100.0 | nM | - |