Assay Detail
Binding
CHEMBL968882
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat NTPDase 1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ectonucleoside triphosphate diphosphohydrolase 1 (CHEMBL2767) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.54 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223344 | RB 2 | — | 1 | 4.70 |
| CHEMBL223145 | — | — | 1 | 4.57 |
| CHEMBL477339 | — | — | 1 | 4.34 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223344 | RB 2 | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL223145 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL477339 | — | Ki | = | 46000.0 | nM | 4.34 |
| CHEMBL265502 | SURAMIN | Ki | = | 300000.0 | nM | - |