Assay Detail
Binding
CHEMBL968883
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat NTPDase 2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ectonucleoside triphosphate diphosphohydrolase 2 (CHEMBL3300) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.39 | 4.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223344 | RB 2 | — | 1 | 4.62 |
| CHEMBL477339 | — | — | 1 | 4.36 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223344 | RB 2 | Ki | = | 24200.0 | nM | 4.62 |
| CHEMBL477339 | — | Ki | = | 44200.0 | nM | 4.36 |
| CHEMBL265502 | SURAMIN | Ki | = | 65400.0 | nM | 4.18 |