Assay Detail
Functional
CHEMBL968900
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 NL4-3 in human MT4 cells assessed as inhibition of virus-induced cytopathogenicity by MTT assay
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 58 | 7.14 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL512432 | — | — | 1 | 9.40 |
| CHEMBL469017 | — | — | 1 | 9.00 |
| CHEMBL511250 | — | — | 1 | 8.70 |
| CHEMBL468352 | — | — | 1 | 8.70 |
| CHEMBL469031 | — | — | 1 | 8.70 |
| CHEMBL469247 | — | — | 1 | 8.40 |
| CHEMBL469016 | — | — | 1 | 8.40 |
| CHEMBL511424 | — | — | 1 | 8.30 |
| CHEMBL506622 | — | — | 1 | 8.30 |
| CHEMBL469015 | — | — | 1 | 8.30 |
| CHEMBL512279 | — | — | 1 | 8.22 |
| CHEMBL83140 | — | — | 1 | 8.22 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.15 |
| CHEMBL199234 | — | — | 1 | 8.15 |
| CHEMBL469239 | — | — | 1 | 8.15 |
| CHEMBL467344 | — | — | 1 | 8.15 |
| CHEMBL469030 | — | — | 1 | 8.05 |
| CHEMBL466949 | — | — | 1 | 7.92 |
| CHEMBL468600 | — | — | 1 | 7.92 |
| CHEMBL512098 | — | — | 1 | 7.82 |
| CHEMBL468360 | — | — | 1 | 7.77 |
| CHEMBL87451 | — | — | 1 | 7.77 |
| CHEMBL512788 | — | — | 1 | 7.72 |
| CHEMBL468601 | — | — | 1 | 7.70 |
| CHEMBL467810 | — | — | 1 | 7.60 |
| CHEMBL108396 | — | — | 1 | 7.52 |
| CHEMBL511415 | — | — | 1 | 7.42 |
| CHEMBL512817 | — | — | 1 | 7.35 |
| CHEMBL468187 | — | — | 1 | 7.34 |
| CHEMBL466948 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL512432 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL469017 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL468352 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL469031 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL511250 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL469247 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL469016 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL511424 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL506622 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL469015 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL512279 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL83140 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL199234 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL469239 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL467344 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL469030 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL466949 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL468600 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL512098 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL468360 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL87451 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL512788 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL468601 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL467810 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL108396 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL511415 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL512817 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL468187 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL466948 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL513342 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL512256 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL259493 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL477985 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL476729 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL468599 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL477143 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL467363 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL477986 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL516745 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL467152 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL476524 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL517665 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL410272 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL468186 | — | EC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL467362 | — | EC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL476300 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL468406 | — | EC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL468848 | — | EC50 | = | 1780.0 | nM | 5.75 |