Assay Detail
Functional
CHEMBL968907
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 isolates with reverse transcriptase Y188L mutation in human MT4 cells assessed as inhibition of virus-induced cytopathogenicity by MTT assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 39 | 5.11 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 5.80 |
| CHEMBL467344 | — | — | 1 | 5.30 |
| CHEMBL469247 | — | — | 1 | 5.26 |
| CHEMBL196807 | — | — | 1 | 5.16 |
| CHEMBL469015 | — | — | 1 | 5.11 |
| CHEMBL511415 | — | — | 1 | 5.05 |
| CHEMBL468600 | — | — | 1 | 5.03 |
| CHEMBL468352 | — | — | 1 | 4.83 |
| CHEMBL469239 | — | — | 1 | 4.44 |
| CHEMBL512432 | — | — | 1 | - |
| CHEMBL467362 | — | — | 1 | - |
| CHEMBL467363 | — | — | 1 | - |
| CHEMBL469031 | — | — | 1 | - |
| CHEMBL512817 | — | — | 1 | - |
| CHEMBL511250 | — | — | 1 | - |
| CHEMBL468599 | — | — | 1 | - |
| CHEMBL468848 | — | — | 1 | - |
| CHEMBL511424 | — | — | 1 | - |
| CHEMBL468601 | — | — | 1 | - |
| CHEMBL512256 | — | — | 1 | - |
| CHEMBL469240 | — | — | 1 | - |
| CHEMBL199234 | — | — | 1 | - |
| CHEMBL259493 | — | — | 1 | - |
| CHEMBL468187 | — | — | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
| CHEMBL468186 | — | — | 1 | - |
| CHEMBL467152 | — | — | 1 | - |
| CHEMBL468360 | — | — | 1 | - |
| CHEMBL512279 | — | — | 1 | - |
| CHEMBL468406 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL467344 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL469247 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL196807 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL469015 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL511415 | — | EC50 | = | 8820.0 | nM | 5.05 |
| CHEMBL468600 | — | EC50 | = | 9380.0 | nM | 5.03 |
| CHEMBL468352 | — | EC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL469239 | — | EC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL512817 | — | EC50 | > | 12000.0 | nM | - |
| CHEMBL469030 | — | EC50 | > | 58000.0 | nM | - |
| CHEMBL511250 | — | EC50 | > | 59000.0 | nM | - |
| CHEMBL468599 | — | EC50 | > | 12000.0 | nM | - |
| CHEMBL468848 | — | EC50 | > | 12000.0 | nM | - |
| CHEMBL511424 | — | EC50 | > | 57000.0 | nM | - |
| CHEMBL468601 | — | EC50 | > | 11000.0 | nM | - |
| CHEMBL506622 | — | EC50 | > | 58000.0 | nM | - |
| CHEMBL469016 | — | EC50 | > | 55000.0 | nM | - |
| CHEMBL469017 | — | EC50 | > | 11000.0 | nM | - |
| CHEMBL512098 | — | EC50 | > | 65000.0 | nM | - |
| CHEMBL467810 | — | EC50 | > | 62000.0 | nM | - |
| CHEMBL466948 | — | EC50 | > | 60000.0 | nM | - |
| CHEMBL466949 | — | EC50 | > | 56000.0 | nM | - |
| CHEMBL512788 | — | EC50 | > | 60000.0 | nM | - |
| CHEMBL469031 | — | EC50 | > | 60000.0 | nM | - |
| CHEMBL467363 | — | EC50 | > | 61000.0 | nM | - |
| CHEMBL467362 | — | EC50 | > | 13000.0 | nM | - |
| CHEMBL512432 | — | EC50 | > | 14000.0 | nM | - |
| CHEMBL512256 | — | EC50 | > | 54000.0 | nM | - |
| CHEMBL469240 | — | EC50 | > | 54000.0 | nM | - |
| CHEMBL199234 | — | EC50 | > | 32000.0 | nM | - |
| CHEMBL259493 | — | EC50 | > | 56000.0 | nM | - |
| CHEMBL468187 | — | EC50 | > | 57000.0 | nM | - |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 7000.0 | nM | - |
| CHEMBL468186 | — | EC50 | > | 11000.0 | nM | - |
| CHEMBL467152 | — | EC50 | > | 59000.0 | nM | - |
| CHEMBL468360 | — | EC50 | > | 54000.0 | nM | - |
| CHEMBL512279 | — | EC50 | > | 40000.0 | nM | - |
| CHEMBL468406 | — | EC50 | > | 12000.0 | nM | - |