Assay Detail
Functional
CHEMBL969264
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Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 48 hrs by LDH reporter assay
10
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.23 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.05 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.91 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 2 | 7.81 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | — | 2 | 5.65 |
| CHEMBL495390 | AZELAIC BIS HYDROXAMIC ACID | — | 2 | 5.26 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | — | 2 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 15.49 | nM | 7.81 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | IC50 | = | 2238.72 | nM | 5.65 |
| CHEMBL495390 | AZELAIC BIS HYDROXAMIC ACID | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL495390 | AZELAIC BIS HYDROXAMIC ACID | IC50 | = | 5495.41 | nM | 5.26 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | IC50 | = | 35700.0 | nM | 4.45 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | IC50 | = | 35481.34 | nM | 4.45 |