Assay Detail
Functional
CHEMBL969265
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH reporter assay
10
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.26 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 9.00 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 2 | 8.01 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.59 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | — | 2 | 5.82 |
| CHEMBL495390 | AZELAIC BIS HYDROXAMIC ACID | — | 2 | 5.41 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | — | 2 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 9.772 | nM | 8.01 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | IC50 | = | 1513.56 | nM | 5.82 |
| CHEMBL495390 | AZELAIC BIS HYDROXAMIC ACID | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL495390 | AZELAIC BIS HYDROXAMIC ACID | IC50 | = | 3890.45 | nM | 5.41 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | IC50 | = | 51300.0 | nM | 4.29 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | IC50 | = | 51286.14 | nM | 4.29 |