Assay Detail
Binding
CHEMBL969512
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Displacement of [125I]T3 from recombinant thyroid hormone receptor alpha expressed in sf9 cells by scintillation proximity assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.54 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1544 | LIOTHYRONINE | 4.0 | 1 | 9.66 |
| CHEMBL41036 | — | — | 1 | 8.14 |
| CHEMBL471488 | MB07344 | -1.0 | 1 | 7.45 |
| CHEMBL471897 | MB07811 | 2.0 | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1544 | LIOTHYRONINE | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL41036 | — | Ki | = | 7.18 | nM | 8.14 |
| CHEMBL471488 | MB07344 | Ki | = | 35.2 | nM | 7.45 |
| CHEMBL471897 | MB07811 | Ki | = | 12500.0 | nM | 4.90 |