Assay Detail
Functional
CHEMBL969583
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase reporter gene assay
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Shh Light II |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.83 | 8.52 |
| EC50 | 2 | 6.85 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473417 | VISMODEGIB | 4.0 | 1 | 8.52 |
| CHEMBL514622 | — | — | 1 | 7.52 |
| CHEMBL516246 | — | — | 1 | 7.40 |
| CHEMBL470513 | — | — | 1 | 7.00 |
| CHEMBL511979 | — | — | 1 | 7.00 |
| CHEMBL470514 | — | — | 1 | 7.00 |
| CHEMBL511978 | — | — | 1 | 7.00 |
| CHEMBL254129 | CYCLOPAMINE | — | 1 | 6.30 |
| CHEMBL471728 | — | — | 1 | 5.30 |
| CHEMBL472994 | — | — | 1 | 5.30 |
| CHEMBL472997 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473417 | VISMODEGIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL514622 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL516246 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL470513 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL511979 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL470514 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL511978 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL254129 | CYCLOPAMINE | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL471728 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL472994 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL472997 | — | IC50 | < | 1.0 | nM | - |