Compound Detail
CHEMBL511978
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Basic Information
| ChEMBL ID | CHEMBL511978 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YZYSKPCSXAEYOV-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
384.5
MW (Da)
5.17
ALogP
5
HBA
1
HBD
59.3
PSA (Ų)
0.47
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sonic hedgehog protein CHEMBL5387 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sonic hedgehog protein | IC50 | = | 100.0 | nM | 7.0 | Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase... | 19309080 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19309080 | 10.1021/jm801420y | Sonic hedgehog protein | 1 |
Data from ChEMBL 36 via Core Engine