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Assay Detail

CHEMBL969630

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Epstein-Barr virus infected in human Akata cells by DNA hybridization assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human gammaherpesvirus 4
Cell Type Akata
Confidence 1 — Organism
Curated By Autocuration

Target

Human gammaherpesvirus 4 (CHEMBL613124)
Type ORGANISM
Organism Human gammaherpesvirus 4

Publication

(Z)- and (E)-2-(1,2-dihydroxyethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine. Synthesis of all stereoisomers, absolute configuration, and antiviral activity.
Zhou S, Drach JC, Prichard MN, Zemlicka J.
J Med Chem (2009) 52 : 3397 -3407
PubMed 19397271 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 4.76 6.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL265948 FILOCICLOVIR 2.0 1 6.66
CHEMBL184 ACYCLOVIR 4.0 1 5.48
CHEMBL491554 1 5.10
CHEMBL450896 1 5.01
CHEMBL489519 1 4.77
CHEMBL489950 1 4.75
CHEMBL445511 1 4.40
CHEMBL521594 1 4.37
CHEMBL489948 1 4.37
CHEMBL506599 1 4.30
CHEMBL492102 1 4.28
CHEMBL491911 1 4.23
CHEMBL509125 1 4.22
CHEMBL492126 1 -
CHEMBL489944 1 -
CHEMBL523282 1 -
CHEMBL489949 1 -
CHEMBL522130 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL265948 FILOCICLOVIR EC50 = 220.0 nM 6.66
CHEMBL184 ACYCLOVIR EC50 = 3300.0 nM 5.48
CHEMBL491554 EC50 = 8000.0 nM 5.10
CHEMBL450896 EC50 = 9800.0 nM 5.01
CHEMBL489519 EC50 = 17000.0 nM 4.77
CHEMBL489950 EC50 = 18000.0 nM 4.75
CHEMBL445511 EC50 = 40000.0 nM 4.40
CHEMBL521594 EC50 = 43000.0 nM 4.37
CHEMBL489948 EC50 = 43000.0 nM 4.37
CHEMBL506599 EC50 = 50400.0 nM 4.30
CHEMBL492102 EC50 = 52600.0 nM 4.28
CHEMBL491911 EC50 = 58700.0 nM 4.23
CHEMBL509125 EC50 = 60000.0 nM 4.22
CHEMBL492126 EC50 > 20000.0 nM -
CHEMBL489944 EC50 > 20000.0 nM -
CHEMBL523282 EC50 > 20000.0 nM -
CHEMBL489949 EC50 > 20000.0 nM -
CHEMBL522130 EC50 > 20000.0 nM -