Assay Detail
Binding
CHEMBL969659
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal flag-tagged Aurora B expressed in Escherichia coli BL21-DE3 by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.99 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259084 | MLN-8054 | 1.0 | 1 | 8.03 |
| CHEMBL523991 | — | — | 1 | 5.85 |
| CHEMBL521949 | — | — | 1 | 5.72 |
| CHEMBL502124 | — | — | 1 | 5.47 |
| CHEMBL508307 | — | — | 1 | 5.43 |
| CHEMBL507170 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259084 | MLN-8054 | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL523991 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL521949 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL502124 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL508307 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL507170 | — | IC50 | = | 3800.0 | nM | 5.42 |