Assay Detail
ADMET
CHEMBL969780
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Growth inhibition of HMVE cells after 72 hrs by alamar blue method
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HMVE |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.49 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442016 | ADAROTENE | — | 1 | 7.00 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | — | 1 | 6.48 |
| CHEMBL116238 | — | — | 1 | 6.47 |
| CHEMBL517254 | — | — | 1 | 6.30 |
| CHEMBL462681 | — | — | 1 | 6.22 |
| CHEMBL495117 | — | — | 1 | - |
| CHEMBL461830 | — | — | 1 | - |
| CHEMBL459492 | — | — | 1 | - |
| CHEMBL459491 | — | — | 1 | - |
| CHEMBL459947 | — | — | 1 | - |
| CHEMBL459738 | — | — | 1 | - |
| CHEMBL461003 | — | — | 1 | - |
| CHEMBL517276 | — | — | 1 | - |
| CHEMBL461647 | — | — | 1 | - |
| CHEMBL516618 | — | — | 1 | - |
| CHEMBL1265 | ADAPALENE | 4.0 | 1 | - |
| CHEMBL516502 | — | — | 1 | - |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | - |
| CHEMBL118143 | — | — | 1 | - |
| CHEMBL492492 | — | — | 1 | - |
| CHEMBL176252 | — | — | 1 | - |
| CHEMBL524028 | — | — | 1 | - |
| CHEMBL493905 | — | — | 1 | - |
| CHEMBL74218 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442016 | ADAROTENE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL116238 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL517254 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL462681 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL495117 | — | IC50 | - | — | - | |
| CHEMBL461830 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL459492 | — | IC50 | - | — | - | |
| CHEMBL459491 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL459947 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL459738 | — | IC50 | - | — | - | |
| CHEMBL461003 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL517276 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL461647 | — | IC50 | - | — | - | |
| CHEMBL516618 | — | IC50 | - | — | - | |
| CHEMBL1265 | ADAPALENE | IC50 | - | — | - | |
| CHEMBL516502 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL38 | TRETINOIN | IC50 | > | 500.0 | nM | - |
| CHEMBL118143 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL492492 | — | IC50 | - | — | - | |
| CHEMBL176252 | — | IC50 | - | — | - | |
| CHEMBL524028 | — | IC50 | - | — | - | |
| CHEMBL493905 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL74218 | — | IC50 | > | 500.0 | nM | - |