Assay Detail
Functional
CHEMBL969786
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human KG1 AML cells after 48 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | AML |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.73 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518627 | — | — | 1 | 6.04 |
| CHEMBL176252 | — | — | 1 | 5.85 |
| CHEMBL461827 | — | — | 1 | 5.30 |
| CHEMBL460351 | — | — | 1 | - |
| CHEMBL460350 | — | — | 1 | - |
| CHEMBL461415 | — | — | 1 | - |
| CHEMBL461199 | — | — | 1 | - |
| CHEMBL459712 | — | — | 1 | - |
| CHEMBL459711 | — | — | 1 | - |
| CHEMBL459710 | — | — | 1 | - |
| CHEMBL459497 | — | — | 1 | - |
| CHEMBL461620 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518627 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL176252 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL461827 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL460351 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL460350 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL461415 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL461199 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL459712 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL459711 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL459710 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL459497 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL461620 | — | IC50 | > | 5000.0 | nM | - |