Assay Detail
Functional
CHEMBL969789
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Antiproliferative activity against human H292 cells after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | H292 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.31 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176252 | — | — | 1 | 6.40 |
| CHEMBL461415 | — | — | 1 | 5.44 |
| CHEMBL461199 | — | — | 1 | 5.41 |
| CHEMBL459497 | — | — | 1 | 5.22 |
| CHEMBL461827 | — | — | 1 | 5.22 |
| CHEMBL518627 | — | — | 1 | 5.17 |
| CHEMBL459710 | — | — | 1 | 4.33 |
| CHEMBL460351 | — | — | 1 | - |
| CHEMBL460350 | — | — | 1 | - |
| CHEMBL459712 | — | — | 1 | - |
| CHEMBL459711 | — | — | 1 | - |
| CHEMBL461620 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176252 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL461415 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL461199 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL459497 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL461827 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL518627 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL459710 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL460351 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL460350 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL459712 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL459711 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL461620 | — | IC50 | > | 5000.0 | nM | - |