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Assay Detail

CHEMBL969852

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against mouse B16F0 cells by Hoechst test
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type B16F0
Confidence 1 — Organism
Curated By Autocuration

Publication

Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma.
Desbois N, Gardette M, Papon J, Labarre P, Maisonial A, Auzeloux P, Lartigue C, Bouchon B, Debiton E, Blache Y, Chavignon O, Teulade JC, Maublant J, Madelmont JC, Moins N, Chezal JM.
Bioorg Med Chem (2008) 16 : 7671 -7690
PubMed 18656367 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 5.82 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL43 AMSACRINE 4.0 1 7.40
CHEMBL3216668 1 6.85
CHEMBL9940 1 6.72
CHEMBL3216669 1 6.38
CHEMBL3215785 1 6.38
CHEMBL3217118 1 6.02
CHEMBL3217119 1 6.01
CHEMBL3215780 1 6.00
CHEMBL1203975 1 5.96
CHEMBL3216900 1 5.96
CHEMBL3216226 1 5.85
CHEMBL1203974 1 5.82
CHEMBL456562 1 5.80
CHEMBL508089 1 5.75
CHEMBL3216227 1 5.70
CHEMBL456561 1 5.52
CHEMBL456779 1 5.43
CHEMBL456140 1 5.28
CHEMBL3216908 1 5.02
CHEMBL456547 1 4.92
CHEMBL3216037 1 4.68
CHEMBL3215781 1 4.65

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL43 AMSACRINE IC50 = 40.0 nM 7.40
CHEMBL3216668 IC50 = 140.0 nM 6.85
CHEMBL9940 IC50 = 190.0 nM 6.72
CHEMBL3216669 IC50 = 420.0 nM 6.38
CHEMBL3215785 IC50 = 420.0 nM 6.38
CHEMBL3217118 IC50 = 950.0 nM 6.02
CHEMBL3217119 IC50 = 980.0 nM 6.01
CHEMBL3215780 IC50 = 990.0 nM 6.00
CHEMBL1203975 IC50 = 1100.0 nM 5.96
CHEMBL3216900 IC50 = 1100.0 nM 5.96
CHEMBL3216226 IC50 = 1400.0 nM 5.85
CHEMBL1203974 IC50 = 1500.0 nM 5.82
CHEMBL456562 IC50 = 1600.0 nM 5.80
CHEMBL508089 IC50 = 1800.0 nM 5.75
CHEMBL3216227 IC50 = 2000.0 nM 5.70
CHEMBL456561 IC50 = 3000.0 nM 5.52
CHEMBL456779 IC50 = 3700.0 nM 5.43
CHEMBL456140 IC50 = 5300.0 nM 5.28
CHEMBL3216908 IC50 = 9500.0 nM 5.02
CHEMBL456547 IC50 = 12000.0 nM 4.92
CHEMBL3216037 IC50 = 21000.0 nM 4.68
CHEMBL3215781 IC50 = 22500.0 nM 4.65