Assay Detail
Binding
CHEMBL969912
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In vivo inhibition of trypsin like 20S proteasome
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
C-terminal constrained phenylalanine as a pharmacophoric unit in peptide-based proteasome inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.48 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188918 | — | — | 1 | 7.30 |
| CHEMBL447652 | — | — | 1 | 7.04 |
| CHEMBL488905 | — | — | 1 | 6.64 |
| CHEMBL448088 | — | — | 1 | 5.74 |
| CHEMBL488718 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188918 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL447652 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL488905 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL448088 | — | IC50 | = | 1815.0 | nM | 5.74 |
| CHEMBL488718 | — | IC50 | = | 2179.0 | nM | 5.66 |