Compound Detail
CHEMBL488718
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CCOC(=O)/C(=C/c1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)c1cccc(O)c1C
Basic Information
| ChEMBL ID | CHEMBL488718 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LVMGFRARMZLAFJ-RFXXUWNZSA-N |
1
Targets
4
Activities
1
Assay Types
1
PK Parameters
2
Publications
0
Known Names
Molecular Properties
551.7
MW (Da)
4.10
ALogP
6
HBA
4
HBD
133.8
PSA (Ų)
0.22
QED
1
Ro5 Violations
13
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.93
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.93 | 5.7875 | 1187.0 | 4 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 6.0 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 1187.0 | nM | 5.93 | Inhibition of chymotrypsin like 20S proteasome activity in lymphoblastoid cells | 17996987 |
| Unchecked | IC50 | = | 1548.0 | nM | 5.81 | In vivo inhibition of chymotrypsin like 20S proteasome | 17996987 |
| Unchecked | IC50 | = | 1761.0 | nM | 5.75 | Inhibition of trypsin like 20S proteasome activity in lymphoblastoid cells | 17996987 |
| Unchecked | IC50 | = | 2179.0 | nM | 5.66 | In vivo inhibition of trypsin like 20S proteasome | 17996987 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17996987 | 10.1016/j.ejmech.2007.10.002 | Unchecked | 6 |
| 17996987 | 10.1016/j.ejmech.2007.10.002 | Plasma | 1 |
Data from ChEMBL 36 via Core Engine