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Assay Detail

CHEMBL970214

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human CCRF-CEM cells after 72 hrs
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CCRF-CEM
Confidence 1 — Organism
Curated By Autocuration

Target

CCRF-CEM (CHEMBL382)
Type CELL-LINE
Organism Homo sapiens

Publication

DNA threading bis(9-aminoacridine-4-carboxamides): effects of piperidine sidechains on DNA binding, cytotoxicity and cell cycle arrest.
He Z, Bu X, Eleftheriou A, Zihlif M, Qing Z, Stewart BW, Wakelin LP.
Bioorg Med Chem (2008) 16 : 4390 -4400
PubMed 18329887 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.75 8.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1554 DACTINOMYCIN 4.0 1 8.80
CHEMBL453718 1 7.00
CHEMBL37656 1 6.92
CHEMBL43 AMSACRINE 4.0 1 6.89
CHEMBL503459 1 6.89
CHEMBL454016 1 6.89
CHEMBL448123 1 6.70
CHEMBL451953 1 6.68
CHEMBL502654 1 6.64
CHEMBL505697 1 6.58
CHEMBL448866 1 6.57
CHEMBL446505 1 6.47
CHEMBL452183 1 6.17
CHEMBL499518 1 6.10
CHEMBL447772 1 5.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1554 DACTINOMYCIN IC50 = 1.6 nM 8.80
CHEMBL453718 IC50 = 99.0 nM 7.00
CHEMBL37656 IC50 = 120.0 nM 6.92
CHEMBL43 AMSACRINE IC50 = 130.0 nM 6.89
CHEMBL503459 IC50 = 130.0 nM 6.89
CHEMBL454016 IC50 = 130.0 nM 6.89
CHEMBL448123 IC50 = 200.0 nM 6.70
CHEMBL451953 IC50 = 210.0 nM 6.68
CHEMBL502654 IC50 = 230.0 nM 6.64
CHEMBL505697 IC50 = 260.0 nM 6.58
CHEMBL448866 IC50 = 270.0 nM 6.57
CHEMBL446505 IC50 = 340.0 nM 6.47
CHEMBL452183 IC50 = 680.0 nM 6.17
CHEMBL499518 IC50 = 800.0 nM 6.10
CHEMBL447772 IC50 = 1100.0 nM 5.96