Assay Detail
Binding
CHEMBL970525
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Inhibition of ASIC3 assessed as inhibition of peak current by patch clamp electrophysiology
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.04 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513153 | — | — | 1 | 6.31 |
| CHEMBL466668 | — | — | 1 | 6.29 |
| CHEMBL467724 | — | — | 1 | 6.19 |
| CHEMBL945 | AMILORIDE | 4.0 | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513153 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL466668 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL467724 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL945 | AMILORIDE | IC50 | = | 4400.0 | nM | 5.36 |