Assay Detail
Binding
CHEMBL970609
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Inhibition of human recombinant SIRT2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.00 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522620 | — | — | 1 | 6.00 |
| CHEMBL523988 | — | — | 1 | 5.32 |
| CHEMBL522968 | — | — | 1 | 4.98 |
| CHEMBL490736 | — | — | 1 | 4.70 |
| CHEMBL491106 | — | — | 1 | 4.65 |
| CHEMBL491960 | CAMBINOL | — | 1 | 4.32 |
| CHEMBL521799 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522620 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL523988 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL522968 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL490736 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL491106 | — | IC50 | = | 22200.0 | nM | 4.65 |
| CHEMBL491960 | CAMBINOL | IC50 | = | 47900.0 | nM | 4.32 |
| CHEMBL521799 | — | IC50 | > | 90000.0 | nM | - |