Assay Detail
Binding
CHEMBL970755
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Inhibition of rat FAAH expressed in Escherichia coli at pH 9.0
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 56 | 7.95 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178398 | — | — | 1 | 9.54 |
| CHEMBL469198 | — | — | 1 | 9.47 |
| CHEMBL426967 | — | — | 1 | 9.25 |
| CHEMBL477372 | — | — | 1 | 9.10 |
| CHEMBL467816 | — | — | 1 | 9.10 |
| CHEMBL220784 | — | — | 1 | 9.05 |
| CHEMBL469199 | — | — | 1 | 9.00 |
| CHEMBL448922 | — | — | 1 | 9.00 |
| CHEMBL450158 | — | — | 1 | 9.00 |
| CHEMBL468188 | — | — | 1 | 9.00 |
| CHEMBL467796 | — | — | 1 | 9.00 |
| CHEMBL469051 | — | — | 1 | 8.96 |
| CHEMBL467368 | — | — | 1 | 8.96 |
| CHEMBL477371 | — | — | 1 | 8.85 |
| CHEMBL466954 | — | — | 1 | 8.80 |
| CHEMBL178115 | — | — | 1 | 8.66 |
| CHEMBL504330 | — | — | 1 | 8.60 |
| CHEMBL467817 | — | — | 1 | 8.52 |
| CHEMBL512965 | — | — | 1 | 8.52 |
| CHEMBL177577 | — | — | 1 | 8.33 |
| CHEMBL468585 | — | — | 1 | 8.30 |
| CHEMBL469050 | — | — | 1 | 8.15 |
| CHEMBL468189 | — | — | 1 | 8.15 |
| CHEMBL512107 | — | — | 1 | 8.15 |
| CHEMBL517352 | — | — | 1 | 8.13 |
| CHEMBL476511 | — | — | 1 | 8.11 |
| CHEMBL219880 | — | — | 1 | 8.10 |
| CHEMBL504091 | — | — | 1 | 8.07 |
| CHEMBL511422 | — | — | 1 | 8.07 |
| CHEMBL177356 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178398 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL469198 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL426967 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL477372 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL467816 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL220784 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL469199 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL448922 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL450158 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL468188 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL467796 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL469051 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL467368 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL477371 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL466954 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL178115 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL504330 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL467817 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL512965 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL177577 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL468585 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL469050 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL468189 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL512107 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL517352 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL476511 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL219880 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL504091 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL511422 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL177356 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL466961 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL461163 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL467140 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL468222 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL476512 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL445514 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL503109 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL469056 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL478186 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL468220 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL178071 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL173992 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL478187 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL455556 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL515490 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL467182 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL478424 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL468221 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL469252 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL512816 | — | Ki | = | 2000.0 | nM | 5.70 |