Assay Detail
Binding
CHEMBL970758
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant FAAH expressed in african green monkey COS7 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.06 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469198 | — | — | 1 | 9.04 |
| CHEMBL178398 | — | — | 1 | 8.92 |
| CHEMBL477372 | — | — | 1 | 8.52 |
| CHEMBL467368 | — | — | 1 | 8.26 |
| CHEMBL177577 | — | — | 1 | 8.05 |
| CHEMBL469051 | — | — | 1 | 7.80 |
| CHEMBL219942 | — | — | 1 | 7.58 |
| CHEMBL461163 | — | — | 1 | 7.43 |
| CHEMBL468220 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469198 | — | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL178398 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL477372 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL467368 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL177577 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL469051 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL219942 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL461163 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL468220 | — | Ki | = | 110.0 | nM | 6.96 |