Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL970761

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of KIAA1363 hydrolase
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Neutral cholesterol ester hydrolase 1 (CHEMBL5048)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.
Garfunkle J, Ezzili C, Rayl TJ, Hochstatter DG, Hwang I, Boger DL.
J Med Chem (2008) 51 : 4392 -4403
PubMed 18630870 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 4.42 4.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL220125 1 4.70
CHEMBL448922 1 4.60
CHEMBL469198 1 4.52
CHEMBL512965 1 4.40
CHEMBL456450 1 4.22
CHEMBL178398 1 4.05
CHEMBL177356 1 -
CHEMBL455556 1 -
CHEMBL177577 1 -
CHEMBL220784 1 -
CHEMBL476511 1 -
CHEMBL450158 1 -
CHEMBL468189 1 -
CHEMBL468188 1 -
CHEMBL467368 1 -
CHEMBL515490 1 -
CHEMBL478187 1 -
CHEMBL476512 1 -
CHEMBL178071 1 -
CHEMBL173992 1 -
CHEMBL219880 1 -
CHEMBL219942 1 -
CHEMBL467796 1 -
CHEMBL426967 1 -
CHEMBL178115 1 -
CHEMBL467817 1 -
CHEMBL461163 1 -
CHEMBL466961 1 -
CHEMBL467182 1 -
CHEMBL469050 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL220125 IC50 = 20000.0 nM 4.70
CHEMBL448922 IC50 = 25000.0 nM 4.60
CHEMBL469198 IC50 = 30000.0 nM 4.52
CHEMBL512965 IC50 = 40000.0 nM 4.40
CHEMBL456450 IC50 = 60000.0 nM 4.22
CHEMBL178398 IC50 = 90000.0 nM 4.05
CHEMBL468189 IC50 > 100000.0 nM -
CHEMBL512107 IC50 > 100000.0 nM -
CHEMBL468188 IC50 > 100000.0 nM -
CHEMBL467368 IC50 > 100000.0 nM -
CHEMBL515490 IC50 > 100000.0 nM -
CHEMBL478187 IC50 > 100000.0 nM -
CHEMBL476512 IC50 > 100000.0 nM -
CHEMBL455556 IC50 > 100000.0 nM -
CHEMBL504330 IC50 > 100000.0 nM -
CHEMBL469051 IC50 > 100000.0 nM -
CHEMBL477372 IC50 > 100000.0 nM -
CHEMBL477371 IC50 > 100000.0 nM -
CHEMBL477167 IC50 > 100000.0 nM -
CHEMBL478424 IC50 > 100000.0 nM -
CHEMBL468222 IC50 > 100000.0 nM -
CHEMBL468221 IC50 > 100000.0 nM -
CHEMBL468220 IC50 > 100000.0 nM -
CHEMBL219942 IC50 > 100000.0 nM -
CHEMBL469050 IC50 > 100000.0 nM -
CHEMBL467182 IC50 > 100000.0 nM -
CHEMBL466961 IC50 > 100000.0 nM -
CHEMBL461163 IC50 > 100000.0 nM -
CHEMBL467817 IC50 > 100000.0 nM -
CHEMBL178115 IC50 > 100000.0 nM -
CHEMBL426967 IC50 > 100000.0 nM -
CHEMBL467796 IC50 > 100000.0 nM -
CHEMBL450158 IC50 > 100000.0 nM -
CHEMBL219880 IC50 = 240000.0 nM -
CHEMBL173992 IC50 > 100000.0 nM -
CHEMBL178071 IC50 > 100000.0 nM -
CHEMBL177356 IC50 > 100000.0 nM -
CHEMBL177577 IC50 > 100000.0 nM -
CHEMBL220784 IC50 > 100000.0 nM -
CHEMBL476511 IC50 > 100000.0 nM -