Assay Detail
Binding
CHEMBL970836
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Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Voltage-gated L-type calcium channel (CHEMBL2095177) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.72 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492668 | — | — | 1 | 6.35 |
| CHEMBL864 | CARBINOXAMINE | 4.0 | 1 | 5.97 |
| CHEMBL275742 | DEXPROPRANOLOL | 2.0 | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492668 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL864 | CARBINOXAMINE | Ki | = | 1080.0 | nM | 5.97 |
| CHEMBL275742 | DEXPROPRANOLOL | Ki | = | 14500.0 | nM | 4.84 |