Assay Detail
Binding
CHEMBL970971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.29 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242740 | TECTORIGENIN | — | 1 | 5.48 |
| CHEMBL128000 | BUTEIN | — | 1 | 5.10 |
| CHEMBL490510 | MAREIN | — | 1 | - |
| CHEMBL45068 | PHLORETIN | — | 1 | - |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242740 | TECTORIGENIN | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL128000 | BUTEIN | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL490510 | MAREIN | IC50 | = | 19000000.0 | nM | - |
| CHEMBL45068 | PHLORETIN | IC50 | = | 25000000.0 | nM | - |
| CHEMBL44 | GENISTEIN | IC50 | = | 0.2 | ug.mL-1 | - |