Assay Detail
Functional
CHEMBL971291
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Inhibition of LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Cell Type | PMNL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lichen metabolites. 1. Inhibitory action against leukotriene B4 biosynthesis by a non-redox mechanism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.00 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 6.40 |
| CHEMBL173395 | ATRANORIN | — | 1 | 5.22 |
| CHEMBL367741 | DIFFRACTAIC ACID | — | 1 | 5.10 |
| CHEMBL490329 | PROTOLICHESTERINIC ACID | — | 1 | 5.05 |
| CHEMBL46469 | ANTHRALIN | 2.0 | 1 | 4.43 |
| CHEMBL493032 | ETHYL HEMATOMMATE | — | 1 | 4.40 |
| CHEMBL367881 | (+)-USNIC ACID | — | 1 | 4.38 |
| CHEMBL470648 | GYROPHORIC ACID | — | 1 | - |
| CHEMBL508287 | ATRARIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL173395 | ATRANORIN | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL367741 | DIFFRACTAIC ACID | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL490329 | PROTOLICHESTERINIC ACID | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL46469 | ANTHRALIN | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL493032 | ETHYL HEMATOMMATE | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL367881 | (+)-USNIC ACID | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL470648 | GYROPHORIC ACID | IC50 | > | 60000.0 | nM | - |
| CHEMBL508287 | ATRARIC ACID | IC50 | > | 60000.0 | nM | - |