Assay Detail
Functional
CHEMBL971401
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Antitrypanosomal activity against Trypanosoma brucei brucei
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.08 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL512274 | — | — | 1 | 7.57 |
| CHEMBL381751 | — | — | 1 | 6.68 |
| CHEMBL468093 | — | — | 1 | 6.05 |
| CHEMBL468092 | — | — | 1 | 5.14 |
| CHEMBL509474 | — | — | 1 | 4.96 |
| CHEMBL466624 | — | — | 1 | - |
| CHEMBL443705 | — | — | 1 | - |
| CHEMBL467047 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL512274 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL381751 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL468093 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL468092 | — | IC50 | = | 7270.0 | nM | 5.14 |
| CHEMBL509474 | — | IC50 | = | 11050.0 | nM | 4.96 |
| CHEMBL466624 | — | IC50 | > | 14000.0 | nM | - |
| CHEMBL443705 | — | IC50 | > | 14000.0 | nM | - |
| CHEMBL467047 | — | IC50 | > | 14000.0 | nM | - |