Assay Detail
Functional
CHEMBL971418
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human Panc 04.03 cells by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.02 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.00 |
| CHEMBL469134 | — | — | 1 | 5.40 |
| CHEMBL511432 | — | — | 1 | 4.84 |
| CHEMBL507592 | — | — | 1 | 4.52 |
| CHEMBL511715 | — | — | 1 | 4.36 |
| CHEMBL466031 | — | — | 1 | - |
| CHEMBL466032 | — | — | 1 | - |
| CHEMBL466033 | — | — | 1 | - |
| CHEMBL468527 | — | — | 1 | - |
| CHEMBL466171 | — | — | 1 | - |
| CHEMBL466459 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL469134 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL511432 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL507592 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL511715 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL466031 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL466032 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL466033 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL468527 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL466171 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL466459 | — | IC50 | > | 50000.0 | nM | - |