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Assay Detail

CHEMBL971453

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of human recombinant CYP1A2
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cytochrome P450 1A2 (CHEMBL3356)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Oxadiazolylindazole sodium channel modulators are neuroprotective toward hippocampal neurones.
Clutterbuck LA, Posada CG, Visintin C, Riddall DR, Lancaster B, Gane PJ, Garthwaite J, Selwood DL.
J Med Chem (2009) 52 : 2694 -2707
PubMed 19341281 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 6.61 8.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL512079 1 8.05
CHEMBL467519 1 7.47
CHEMBL448430 1 7.21
CHEMBL466917 1 7.08
CHEMBL525607 1 6.68
CHEMBL466715 1 6.50
CHEMBL511401 1 6.44
CHEMBL466871 1 6.10
CHEMBL513130 1 5.31
CHEMBL511893 1 5.23
CHEMBL511924 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL512079 IC50 = 9.0 nM 8.05
CHEMBL467519 IC50 = 34.0 nM 7.47
CHEMBL448430 IC50 = 62.0 nM 7.21
CHEMBL466917 IC50 = 84.0 nM 7.08
CHEMBL525607 IC50 = 210.0 nM 6.68
CHEMBL466715 IC50 = 315.0 nM 6.50
CHEMBL511401 IC50 = 360.0 nM 6.44
CHEMBL466871 IC50 = 790.0 nM 6.10
CHEMBL513130 IC50 = 4860.0 nM 5.31
CHEMBL511893 IC50 = 5920.0 nM 5.23
CHEMBL511924 IC50 > 10000.0 nM -